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NAPLEX Practice Exam A

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NAPLEX Practice Questions

1 / 10

1. Which medications are used in the initial 2-month phase for tuberculosis?

A. Rifampin, Isoniazid, Linezolid, Ethambutol

B. Isoniazid, Ethambutol, Levofloxacin, Pyrazinamide

C. Rifampin, Isoniazid, Pyrazinamide, Ethambutol

D. Rifampin, Amikacin, Pyrazinamide, Moxifloxacin

E. Isoniazid, Rifampin, Bedaquiline, Ethionamide

The initial treatment for wild-type TB includes four first-line drugs known as the RIPE regimen: Rifampin, Isoniazid, Pyrazinamide, and Ethambutol. These drugs are used together in the intensive phase to reduce bacterial load and prevent resistance.

2 / 10

2. Which auxiliary labels should accompany a benzodiazepine prescription?

A. Controlled substance warning

B. May cause drowsiness

C. Avoid alcohol

D. May impair driving

E. All of the above

All are appropriate due to CNS effects, abuse potential, and safety risks.

3 / 10

3. A patient hospitalized with acute myocardial infarction. What statin should they be started on to reduce risk of recurrent ischemia?

A. Simvastatin 40 mg

B. Lovastatin 80 mg

C. Rosuvastatin 10 mg

D. Atorvastatin 80 mg

E. Pravastatin 40 mg

High-intensity statins like atorvastatin 80 mg improve outcomes post-MI when started promptly.

4 / 10

4. Paul a 45 year-old male has diabetes and no prior adult vaccines. It’s October. Which vaccines should be recommended?

A. Pneumovax 23 + Fluvarin

B. Prevnar 20 + Fluvarin

C. Pneumovax 23 + Flumist

D. Prevnar 13 + Flumist

E. Shingles vaccine

Paul is under 65 but has diabetes, which places him in a high-risk group for pneumococcal disease. Current ACIP guidelines recommend: Pneumococcal vaccination: Patients aged 19–64 with diabetes should receive either: PCV20 alone, or PCV15 followed by PPSV23 (at least 1 year apart, or 8 weeks in immunocompromised).
Annual influenza vaccination: He should receive an inactivated influenza vaccine like Fluvarin. FluMist is not recommended in high-risk patients (e.g., diabetes, chronic conditions). Shingles vaccine (Shingrix) is approved for immunocompetent adults ?50 years or ?19 if immunocompromised, so Peter does not yet qualify based on age alone.

5 / 10

5. A prefilled syringe contains 75 mg of phenylephrine hydrochloride per 3 mL. Express the % concentration (w/v).

A. 0.25%

B. 10%

C. 2.5%

D. 1%

E. 0.1%

% = (75 mg / 3 mL) x (100mL/1000mg) = 2.5%

6 / 10

6. If 200 capsules contain 600 mg of an active ingredient, how much is in 84 capsules?

A. 252 mg

B. 323 mg

C. 224 mg

D. 324 mg

E. 22.4 mg

600 mg ÷ 200 = 3 mg each --> 84 × 3 = 252 mg

7 / 10

7. Which chemotherapy drugs have restricted lifetime dosing due to cumulative toxicity risks?

A. Idarubicin

B. Epirubicin

C. Daunorubicin

D. Doxorubicin

E. All of the above

Anthracyclines like doxorubicin, daunorubicin, idarubicin, and epirubicin have lifetime dose limits due to risk of cardiotoxicity.

8 / 10

8. A 45-year-old patient is diagnosed with diabetes. The patient has past medical history of chronic kidney disease (eGFR 25) and heartfailure. What is the most appropriate first line therapy for the patient?

A. exenatide

B. lixisenatide

C. canagliflozin

D. empagliflozin

E. B or D

In patients with type 2 diabetes and established CVD or heart failure, SGLT2 inhibitors have shown both cardiovascular and renal benefit. Empagliflozin specifically is indicated for use in patients with HFrEF and CKD, including those with eGFR ?20, depending on the specific agent and FDA label. Canagliflozin should be avoided in eGFR <30. Exenatide and lixisenatide (GLP-1 receptor agonists) primarily show benefit in reducing atherosclerotic cardiovascular disease (ASCVD) events, like stroke or myocardial infarction, but not heart failure–specific outcomes.

9 / 10

9. A patient is receiving hydromorphone 4 mg orally every 6 hours for severe chronic pain. The provider wants to switch the patient to oral morphine without dose reduction for insurance coverage reasons. What is the appropriate total daily oral morphine equivalent dose?

A. 24 mg oral morphine per day

B. 48 mg oral morphine per day

C. 64 mg oral morphine per day

D. 80 mg oral morphine per day

E. 120 mg oral morphine per day

Oral hydromorphone to oral morphine conversion ratio ≈ 1:5.
4 mg Q6H = 16 mg hydromorphone/day
16 mg × 5 = 80 mg morphine/day

10 / 10

10. An 72-year-old female has T-scores of -4.2 in her spine and -3.4 in her right hip without history of fractures. What condition is indicated?

A. More testing is needed to make a diagnosis.

B. These results indicate osteopenia.

C. These results indicate osteoporosis.

D. The patient does not have osteopenia or osteoporosis.