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NAPLEX Practice Exam A

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NAPLEX Practice Questions

1 / 10

1. How many grams of NaCl are in 600 mL of 1/2 NS?

A. 1 gram

B. 10 grams

C. 2.25 grams

D. 2.7 grams

E. 4.5 grams

1/2 NS = 0.45% NaCl = 0.0045 g/mL --> 600 mL × 0.0045 g/mL = 2.7 g

2 / 10

2. What is the correct way to use the Daytrana patch?

A. Apply to the hip 2 hours before the medication is needed

B. Replace weekly

C. Switch application site on opposite hip every week

D. Press patch for 5 seconds when applying

E. Remove during bathing or showering

Daytrana is applied daily, to the hip, 2 hours before effect is desired, and held for 30 seconds. Alternate hips daily. It is water-resistant.

3 / 10

3. A patient is admitted with ataxia, dizziness, and slurred speech. Phenytoin toxicity is suspected. Laboratory values show: phenytoin level 12.6 mcg/mL (therapeutic 10-20 mcg/mL) and albumin 1.6 g/dL (normal range 3.6-5.1 g/dL). What is the most appropriate interpretation of these findings?

A. Albumin level is actually higher

B. Albumin level is actually lower

C. Phenytoin level is actually higher

D. Phenytoin level is actually lower

E. None of the above

Low albumin means more free (active) phenytoin, making the effective level higher than what appears in labs.

4 / 10

4. Which medications are used in the initial 2-month phase for tuberculosis?

A. Rifampin, Isoniazid, Linezolid, Ethambutol

B. Isoniazid, Ethambutol, Levofloxacin, Pyrazinamide

C. Rifampin, Isoniazid, Pyrazinamide, Ethambutol

D. Rifampin, Amikacin, Pyrazinamide, Moxifloxacin

E. Isoniazid, Rifampin, Bedaquiline, Ethionamide

The initial treatment for wild-type TB includes four first-line drugs known as the RIPE regimen: Rifampin, Isoniazid, Pyrazinamide, and Ethambutol. These drugs are used together in the intensive phase to reduce bacterial load and prevent resistance.

5 / 10

5. A 45-year-old patient is diagnosed with diabetes. The patient has past medical history of chronic kidney disease (eGFR 25) and heartfailure. What is the most appropriate first line therapy for the patient?

A. exenatide

B. lixisenatide

C. canagliflozin

D. empagliflozin

E. B or D

In patients with type 2 diabetes and established CVD or heart failure, SGLT2 inhibitors have shown both cardiovascular and renal benefit. Empagliflozin specifically is indicated for use in patients with HFrEF and CKD, including those with eGFR ?20, depending on the specific agent and FDA label. Canagliflozin should be avoided in eGFR <30. Exenatide and lixisenatide (GLP-1 receptor agonists) primarily show benefit in reducing atherosclerotic cardiovascular disease (ASCVD) events, like stroke or myocardial infarction, but not heart failure–specific outcomes.

6 / 10

6. A glaucoma patient with COPD requires a beta blocker eye drop. Which is the safest option?

A. Timolol

B. Levobunolol

C. Carteolol

D. Nadolol

E. Betaxolol

Betaxolol is beta-1 selective and less likely to exacerbate respiratory conditions. The others are non-selective.

7 / 10

7. An 75-year-old male with end stage renal disease is currently on venlafaxine, warfarin, lisinopril, and potassium. He had a recent serious bleed. What is the most likely cause?

A. Bleeding risk from warfarin and lisinopril

B. Increased bleed risk from warfarin and venlafaxine

C. Fall risk due to end stage renal disease and venlafaxine

D. A and B

E. None of the above

SSRIs/SNRIs like venlafaxine increase bleeding risk when used with anticoagulants such as warfarin.

8 / 10

8. A patient is receiving 400 mL of 10% Intralipid weekly. How many kcal from lipids are provided daily?

A. 62.9 kcal

B. 550 kcal

C. 78.6 kcal

D. 74.8 kcal