NAPLEX Practice Questions

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🎯 Free NAPLEX Practice Questions
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Disclaimer: These practice questions are intended as a study aid and do not cover all topics that may appear on the NAPLEX. Questions are periodically reviewed and updated, but it remains the user’s responsibility to stay informed on the most current clinical guidelines and NAPLEX content areas. Always refer to the latest official sources and recommendations when preparing for the exam.

NAPLEX Practice Questions

1 / 10

1. A patient reports ankle swelling after starting pregabalin. Where should this adverse effect be reported?

A. The Red Book

B. The Orange Book

C. The Pink Sheet

D. MedWatch

E. CMS

2 / 10

2. A 40-year-old male with atrial fibrillation has been on long-term warfarin 2 mg daily, well controlled. He recently started amiodarone and sertraline with no changes to warfarin dosing. He was admitted to the emergency room with bleeding gums and black tarry stool. The INR at the emergency room was 8 with hemoglobin 8.3 g/dL. What is the correct course of action:

A. Hold warfarin and give 1–2.5 mg vitamin K orally.

B. Omit next 1–2 doses and monitor INR.

C. Hold warfarin and give 2 mg vitamin K SC.

D. Hold warfarin and give vitamin K 10 mg slow IV infusion.

E. Hold warfarin and give vitamin K 10 mg IM.

3 / 10

3. A patient with treatment-resistant schizophrenia is being considered for clozapine therapy. What is the minimum WBC count needed to begin this medication?

A. 11,500/mm³

B. 7,500/mm³

C. 4,500/mm³

D. 3,500/mm³

E. 5,500/mm³

4 / 10

4. What is the correct way to use the Daytrana patch?

A. Apply to the hip 2 hours before the medication is needed

B. Replace weekly

C. Switch application site on opposite hip every week

D. Press patch for 5 seconds when applying

E. Remove during bathing or showering

5 / 10

5. Which medications are used in the initial 2-month phase for tuberculosis?

A. Rifampin, Isoniazid, Linezolid, Ethambutol

B. Isoniazid, Ethambutol, Levofloxacin, Pyrazinamide

C. Rifampin, Isoniazid, Pyrazinamide, Ethambutol

D. Rifampin, Amikacin, Pyrazinamide, Moxifloxacin

E. Isoniazid, Rifampin, Bedaquiline, Ethionamide

6 / 10

6. An 75-year-old male with end stage renal disease is currently on venlafaxine, warfarin, lisinopril, and potassium. He had a recent serious bleed. What is the most likely cause?

A. Bleeding risk from warfarin and lisinopril

B. Increased bleed risk from warfarin and venlafaxine

C. Fall risk due to end stage renal disease and venlafaxine

D. A and B

E. None of the above

7 / 10

7. A patient using erythropoietin for eight months. She woke up today having pain and swelling below the knees. What is the most likely complication?

A. Arthralgia

B. Myalgia

C. Deep vein thrombosis

D. Osteosarcoma

E. Peripheral neuropathy

8 / 10

8. How many grams of NaCl are in 600 mL of 1/2 NS?

A. 1 gram

B. 10 grams

C. 2.25 grams

D. 2.7 grams

E. 4.5 grams

9 / 10

9. The pharmacy receives the following TPN order. Calculate the volume of 23.4% NaCl (4 mEq/mL) that should be added to the TPN.
Item/Quantities:
Dextrose 270 g
Amino acids 60 g
Sodium chloride 44 mEq
Sodium acetate 14 mEq
Potassium 40 mEq
Magnesium sulfate 10 mEq
Phosphate 21 mmol
Calcium 4.45 mEq
Sterile water qs ad 980 mL

A. 95 mL

B. 152 mL

C. 38 mL

D. 17 mL

E. 11 mL

10 / 10

10. A pharmacist dissolves 3 ketoconazole tablets, each containing 200 mg, into a base to prepare 30 mL of a topical solution. What is the % strength (w/v)?

A. 1.8%

B. 2%

C. 2.5%

D. 1.5%

E. 0.2%

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