NAPLEX Practice Questions

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🎓 FREE NAPLEX Practice Questions – Test Your Knowledge Now!

🎯 Free NAPLEX Practice Questions
Test your knowledge with a mix of high-yield, exam-style questions.

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Disclaimer: These practice questions are intended as a study aid and do not cover all topics that may appear on the NAPLEX. Questions are periodically reviewed and updated, but it remains the user’s responsibility to stay informed on the most current clinical guidelines and NAPLEX content areas. Always refer to the latest official sources and recommendations when preparing for the exam.

NAPLEX Practice Questions

1 / 10

1. Amy takes dornase alfa for cystic fibrosis. What is the correct statement regarding dornase alfa?

A. Reduces mucus viscosity and improves airflow

B. Taken as a 25 mg ampule nebulized daily

C. Store at room temp and protect from light

D. Brand name is Xolair

E. All of the above

2 / 10

2. A glaucoma patient with COPD requires a beta blocker eye drop. Which is the safest option?

A. Timolol

B. Levobunolol

C. Carteolol

D. Nadolol

E. Betaxolol

3 / 10

3. A 78-year-old woman prescribed oxybutynin ER for overactive bladder is most likely to experience which side effect?

A. Hypoglycemia

B. Orthostatic hypotension

C. Dry mouth

D. Tachycardia

E. Rash

4 / 10

4. A patient is admitted with ataxia, dizziness, and slurred speech. Phenytoin toxicity is suspected. Laboratory values show: phenytoin level 12.6 mcg/mL (therapeutic 10-20 mcg/mL) and albumin 1.6 g/dL (normal range 3.6-5.1 g/dL). What is the most appropriate interpretation of these findings?

A. Albumin level is actually higher

B. Albumin level is actually lower

C. Phenytoin level is actually higher

D. Phenytoin level is actually lower

E. None of the above

5 / 10

5. A patient taking levothyroxine also uses OTC medications for heartburn. Which of the following is least likely to interfere with thyroid hormone absorption?

A. Magnesium hydroxide

B. Calcium carbonate

C. Famotidine

D. Pepcid Complete

E. C and D only

6 / 10

6. A 45-year-old male on warfarin, digoxin, carvedilol and amiodarone wants to use Pepto-Bismol for diarrhea. What is the pharmacist’s primary concern?

A. Risk of arrhythmia

B. Risk of bradycardia

C. Risk of digoxin toxicity

D. Risk of bleeding

E. Risk of heart block

7 / 10

7. Aurora has monthly migraines triggered by her menstrual cycle which is accompanied by heavy bleeding. Which option would be appropriate to prevent migraines in her case?

A. Sumatriptan

B. Propranolol to reduce migraines

C. Oral contraceptives

D. A migraine patch

E. Fioricet for pain management

8 / 10

8. A heart failure patient was started on Vasotec 2.5mg twice daily and Toprol XL 25 mg daily. During the one month follow-up the patient's blood pressure is 120/80 mmgHg and heart rate at 75 BPM. The patient developed a dry cough and drinking water doesn't help. What medication changes are appropriate?

A. Use OTC cough suppressant

B. Stop Toprol XL and start carvedilol

C. Switch from Vasotec to Diovan

D. Reduce Toprol XL dose

E. Reduce Vasotec dose

9 / 10

9. A woman presents prescriptions for PegIntron once weekly and ribavirin for hepatitis B. What should the pharmacist do?

A. Fill as written.

B. Do not fill; the patient should not be taking this combination for hepatits B

C. Do not fill; triple therapy is needed for hepatitis B

D. Do not fill; dangerous drug interaction between PegIntron and ribavirin

E. Do not fill; PegIntron should be given daily

10 / 10

10. A patient has a prolonged QT interval. Which antiarrhythmic poses the least additional QT risk?

A. Quinidine

B. Procainamide

C. Dofetilide

D. Diltiazem

E. Amiodarone

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