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NAPLEX Practice Exam A

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NAPLEX Practice Questions

1 / 10

1. James is a 65-year-old male newly prescribed tamsulosin for benign prostatic hyperplasia. Which of the following statements is correct?

A. The correct dose is 4 mg daily

B. Tamsulosin is a dopamine agonist

C. Tamsulosin blocks alpha-1 receptors in prostate tissue

D. It causes frequent erectile dysfunction

E. It is only used for prostate cancer

Tamsulosin blocks alpha-1 receptors in the prostate to improve urinary flow. The standard dose is 0.4 mg daily.

2 / 10

2. Travis smokes 1.5–2 packs/day. What is the correct starting dose of nicotine gum?

A. 8 mg gum

B. 6 mg gum

C. 4 mg gum

D. 2 mg gum

E. 1 mg gum

Smokers >25 cigarettes/day should start with 4 mg gum. 2 mg is for lighter smokers. There are 20 cigarettes in 1 pack.

3 / 10

3. A patient using erythropoietin for eight months. She woke up today having pain and swelling below the knees. What is the most likely complication?

A. Arthralgia

B. Myalgia

C. Deep vein thrombosis

D. Osteosarcoma

E. Peripheral neuropathy

ESAs increase the risk of thrombotic events like DVT; patients should be monitored for signs of clots.

4 / 10

4. What is the correct way to use the Daytrana patch?

A. Apply to the hip 2 hours before the medication is needed

B. Replace weekly

C. Switch application site on opposite hip every week

D. Press patch for 5 seconds when applying

E. Remove during bathing or showering

Daytrana is applied daily, to the hip, 2 hours before effect is desired, and held for 30 seconds. Alternate hips daily. It is water-resistant.

5 / 10

5. Paul a 45 year-old male has diabetes and no prior adult vaccines. It’s October. Which vaccines should be recommended?

A. Pneumovax 23 + Fluvarin

B. Prevnar 20 + Fluvarin

C. Pneumovax 23 + Flumist

D. Prevnar 13 + Flumist

E. Shingles vaccine

Paul is under 65 but has diabetes, which places him in a high-risk group for pneumococcal disease. Current ACIP guidelines recommend: Pneumococcal vaccination: Patients aged 19–64 with diabetes should receive either: PCV20 alone, or PCV15 followed by PPSV23 (at least 1 year apart, or 8 weeks in immunocompromised).
Annual influenza vaccination: He should receive an inactivated influenza vaccine like Fluvarin. FluMist is not recommended in high-risk patients (e.g., diabetes, chronic conditions). Shingles vaccine (Shingrix) is approved for immunocompetent adults ?50 years or ?19 if immunocompromised, so Peter does not yet qualify based on age alone.

6 / 10

6. If 1 gallon of a 20% (w/v) solution is evaporated to a solution with a 40% (w/v) strength, what will be the new volume (in mL)?

A. 710 mL

B. 1666 mL

C. 1776 mL

D. 1893 mL

E. 2840 mL

1 gal = 3785 mL --> 3785×0.20 = V2×0.40 --> V2 = 1892.5 mL

7 / 10

7. A 62-year-old man taking tamsulosin is prescribed sildenafil for erectile dysfunction. What should the pharmacist advise?

A. The combination is contraindicated.

B. He should be warned about dizziness and fainting.

C. Start sildenafil at 25 mg daily.

D. Switch to terazosin instead.

E. None of the above

PDE5 inhibitors like sildenafil can cause significant hypotension when used with alpha blockers like tamsulosin or terazosin. Counsel on symptoms and slow position changes.

8 / 10

8. A patient decideds to take OTC pseudoephedrine for bad congestion. Which is a known side effect of pseudoephedrine?

A. Tachycardia

B. Drowsiness

C. Increased appetite

D. Decreased blood pressure

E. All of the above

Pseudoephedrine stimulates adrenergic receptors, causing tachycardia, insomnia, and appetite suppression.

9 / 10

9. Aurora has monthly migraines triggered by her menstrual cycle which is accompanied by heavy bleeding. Which option would be appropriate to prevent migraines in her case?

A. Sumatriptan

B. Propranolol to reduce migraines

C. Oral contraceptives

D. A migraine patch

E. Fioricet for pain management

Oral contraceptives are a reasonable option for managing both pre-menstrual migraines and heavy menstrual bleeding, addressing both issues simultaneously.

10 / 10

10. Select the mechanism of action of donepezil:

A. Decarboxylase inhibitor

B. Norepinephrine reuptake inhibitor

C. Acetylcholinesterase inhibitor

D. Anticholinergic

E. NMDA-receptor antagonist

Donepezil works as an acetylcholinesterase inhibitor to increase acetylcholine levels in the brain, which is helpful in Alzheimer's disease.

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