NAPLEX Practice Questions

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🎯 Free NAPLEX Practice Questions
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Disclaimer: These practice questions are intended as a study aid and do not cover all topics that may appear on the NAPLEX. Questions are periodically reviewed and updated, but it remains the user’s responsibility to stay informed on the most current clinical guidelines and NAPLEX content areas. Always refer to the latest official sources and recommendations when preparing for the exam.

NAPLEX Practice Questions

1 / 10

1. A patient is admitted with ataxia, dizziness, and slurred speech. Phenytoin toxicity is suspected. Laboratory values show: phenytoin level 12.6 mcg/mL (therapeutic 10-20 mcg/mL) and albumin 1.6 g/dL (normal range 3.6-5.1 g/dL). What is the most appropriate interpretation of these findings?

A. Albumin level is actually higher

B. Albumin level is actually lower

C. Phenytoin level is actually higher

D. Phenytoin level is actually lower

E. None of the above

2 / 10

2. A 67-year-old man presents to the emergency department 1 hour after the sudden onset of right-sided weakness and slurred speech which occured 1 hr ago. A non-contrast CT scan of the head shows no evidence of hemorrhage. His blood pressure is 190/92 mmHg, and blood glucose is 110 mg/dL. His past medical history includes hypertension, type 2 diabetes, and peptic ulcer disease. His current medications include lisinopril, metformin, enoxaparin, and aspirin. Further review of the electronic medical record reveals that he underwent a lumbar laminectomy 10 days ago.

Which of the following is the most appropriate next step regarding administration of alteplase (tPA)?

A. Administer alteplase within the next 2 hours.

B. Do not administer alteplase due to recent surgery.

C. Administer alteplase after administering a loading dose of aspirin.

D. Administer alteplase only if blood pressure is lowered to below 185/110 mmHg.

E. Administer alteplase after discontinuing enoxaparin for 24 hours

3 / 10

3. Aurora has monthly migraines triggered by her menstrual cycle which is accompanied by heavy bleeding. Which option would be appropriate to prevent migraines in her case?

A. Sumatriptan

B. Propranolol to reduce migraines

C. Oral contraceptives

D. A migraine patch

E. Fioricet for pain management

4 / 10

4. What is the correct wear time for the scopolamine patch?

A. 1 day

B. 2 days

C. 3 days

D. 5 days

E. 7 days

5 / 10

5. James is a 65-year-old male newly prescribed tamsulosin for benign prostatic hyperplasia. Which of the following statements is correct?

A. The correct dose is 4 mg daily

B. Tamsulosin is a dopamine agonist

C. Tamsulosin blocks alpha-1 receptors in prostate tissue

D. It causes frequent erectile dysfunction

E. It is only used for prostate cancer

6 / 10

6. A prefilled syringe contains 75 mg of phenylephrine hydrochloride per 3 mL. Express the % concentration (w/v).

A. 0.25%

B. 10%

C. 2.5%

D. 1%

E. 0.1%

7 / 10

7. How many grams of dextrose are in 750 mL of D5W?

A. 10 grams

B. 25 grams

C. 37.5 grams

D. 50 grams

E. 125 grams

8 / 10

8. A patient with treatment-resistant schizophrenia is being considered for clozapine therapy. What is the minimum WBC count needed to begin this medication?

A. 11,500/mm³

B. 7,500/mm³

C. 4,500/mm³

D. 3,500/mm³

E. 5,500/mm³

9 / 10

9. What is the correct way to use the Daytrana patch?

A. Apply to the hip 2 hours before the medication is needed

B. Replace weekly

C. Switch application site on opposite hip every week

D. Press patch for 5 seconds when applying

E. Remove during bathing or showering

10 / 10

10. A 45-year-old patient is diagnosed with diabetes. The patient has past medical history of chronic kidney disease (eGFR 25) and heartfailure. What is the most appropriate first line therapy for the patient?

A. exenatide

B. lixisenatide

C. canagliflozin

D. empagliflozin

E. B or D

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